,29 ; Goto, M.; Moniruzzaman, M. Screening of ionic liquids for the extraction of biologically active compounds using emulsion liquid membrane: COSMO-RS prediction and experiments. Clearance Center request page. In addition, the screening of ILs using COSMO-RS for Ibf has not been extensively performed. 44 sieves. 22 and no. National Library of Medicine Glycerol was not very effective in increasing the aqueous solubilities of both compounds, whereas sorbitol solution had a minimal effect on their solubility. 26 ; Coutinho, J.A. The solubility of ibuprofen in pure solvents decreased in the following order: DMSO > methanol > ethanol > isopropanol > n-propanol > PEG-200 > PG > water. Experimental verification was carried out using the ILGELM. #webform-submission-headshot-update-request-add-form div.tabledrag-toggle-weight-wrapper,.field-suffix { Most of the studies for Ibf extraction were carried out using imidazolium [, This section presents the results obtained using COSMO-RS for Ibf, the development of the ILGELM using the screened IL, and an experimental validation. The bulk volume of the porous mass was then noted in terms of expansion ratio. Calculate the average mass of ibuprofen in a tablet and compare this result with the manufacturer's claim as shown on the packet of tablets. The DSC thermogram peak at 67.77C indicated the presence of ibuprofen in the porous solid dispersion at the molecular level. The pores in the mass act as capillaries due to surface force, and liquid is drawn into these capillaries spontaneouslya phenomenon called capillarity., This phenomenon can be expressed by following equation:19. where h is the height above the liquid to which the liquid rises in a capillary, r is the radius, d is the density of the liquid, is the surface tension of water, is the angle of contact, and g is the acceleration due to gravity. ; Kamonwel, N.D. Study of the ionic liquids electrochemical reduction using experimental and computational methods. /* strategic plan */ ; Ventura, S.P. https://doi.org/10.3390/molecules28052345, Khan HW, Elgharbawy AAM, Bustam MA, Goto M, Moniruzzaman M. Ionic Liquid-Based Green Emulsion Liquid Membrane for the Extraction of the Poorly Soluble Drug Ibuprofen. Jeliski, T.; Cysewski, P. Screening of ionic liquids for efficient extraction of methylxanthines using COSMO-RS methodology. Several previous studies have explored the increment of with temperature and the addition of some organic co-solvents [60, 61]. Cheesecloth has a larger mesh and cannot be used for this extraction. } Due to environmental Topical drug products and cosmetics are often manufactured in the same facility under a unified quality standard that supports the topical drug products performance and label claims. 44 were used further to characterize and evaluate solid dispersion. max-width: 100%; The experimental results indicated that the predicted COSMO-RS and the experimental results were in good agreement. margin-bottom: 15px; The resulting two-in-one product can greatly enhance the dissolution rate by simultaneously exploiting two techniques: solid dispersion and capillarity. please go to the Copyright Clearance Center request page. Results shown in Tables 14 indicate that a higher concentration of the drug in a porous solid dispersion decreases the products porosity. /* hide topics on page */ border-color: #08acd5; ; Khalil, M.A.B. } Funder: Y-UTP, Universiti Teknologi PETRONAS; Grant Number: 015LC0-264. -ms-flex-direction:column; Ibuprofen is a carboxylic acid, it will react with bases to produce a salt and water. This enhances a solid drug products dissolution rate and content uniformity. If you are an author contributing to an RSC publication, you do not need to request permission Haron, G.A. This site needs JavaScript to work properly. positive feedback from the reviewers. 2023; 28(5):2345. Phase solubility studies were carried out to compare the saturation solubilities of racIB and SIB in the presence of common pharmaceutical solvents such as glycerol, sorbitol solution, propylene glycol (PG), and polyethylene glycol (PEG 300) over the range of 20% to 80% v/v in aqueous based systems. padding: 1.5rem; It can be also be expressed as: where C0 is the initial concentration of drug, k is the first-order rate constant, and t is the time.26 } /* fix flex col 3 */ Solubility of ibuprofen in the following dissolution media was evaluated: buffer pH 7.2, 6.8, 4.5, and 0.1 N HCl. Al-Odaini, N.A. There are many preparations of codeine and ibuprofen available over the counter in the UK. Usually, conventional solvents are employed for the separation and recovery of ibuprofen. } Ibu presents a hydrophilic head, the carboxylic group, and a hydrophobic tail. Ionic liquid assisted cellulose aerogels for cleaning an oil spill. ISPE Europe Annual Conference, 8th to 10th May 2023 - What You Need to Know about the GAMP Track! Feature papers represent the most advanced research with significant potential for high impact in the field. Multiple requests from the same IP address are counted as one view. The purpose of this research was to investigate the mechanism of solubilization of a model drug, ibuprofen, in cosolvent-water mixtures by applying enthalpy-entropy compensation analysis. After studying Tables 14, the additional following conclusions can be drawn: In sum, the following conditions must be maintained to obtain maximum porosity in the porous solid dispersion: Fourier-transform infrared (FTIR) spectroscopy studies were performed to evaluate the possible interaction between the polymer and the drug. The graph is plotted as the percentage of cumulative drug release vs. the square root of time. Islam, N.; Khan, H.W. ; Goto, M.; Moniruzzaman, M. Ionic Liquid-Based Green Emulsion Liquid Membrane for the Extraction of the Poorly Soluble Drug Ibuprofen. /* fix flex col 3 */ The viscous solution was heated until it reached its boiling point and subjected to vacuum at 760 mmHg to yield porous solid dispersion and then collected in a beaker. Would you like email updates of new search results? At low cosolvent mole fraction, up to the maximum in enthalpy and entropy versus composition curves, the solubility of ibuprofen was entropy driven while beyond the peaks, the solubility of ibuprofen was enthalpy driven. Codeine will begin to decompose at temperatures above 60C[1], so hot or boiling water should not be used in this extraction. background-repeat: no-repeat; background: #00aad4; Fallanza, M.; Gonzlez-Miquel, M.; Elia, R.; Alfredo, O.; Gorri, D.; Palomar, J.; Ortiz, I. There are generic versions available in some pharmacies, but these may have reduced codeine content and may not be much cheaper per mg. Also available in the UK is the branded product Paramol in pack sizes of 12, 24 and 32 tablets, each containing 7.46mg dihydrocodeine tartrate and 500mg paracetamol. Next, 4 g of PVP were added to the solution, with constant stirring, to obtain uniform distribution of the drug in the viscous solution. Huang, Y.; Ji, Y.; Zhang, M.; Ouyang, D. How imidazolium-based ionic liquids solubilize the poorly soluble ibuprofen? In waterethanol mixtures, the solubility of ibuprofen (expressed as w/w ibuprofen/solvent) generally decreased with increasing water addition. The dissolution study of ibuprofen delivered by poloxamer gels composed of poloxamer 188 and menthol were performed. We prepared solid dispersion of ibuprofen with PVP K-30 using a 10% concentration of the drug to the total weight of the carrier. The XRD study of the porous solid dispersion showed peaks for pure ibuprofen and PVP K-30, indicating that there was no chemical interaction between the drug and the carrier. background: #00aad4; Fortunately, formulation scientists can use different technological approaches to resolve this challenge.3, After screening physicochemical and biopharmaceutical properties of various drug candidates, ibuprofen was selected for the present study due to its poor bioavailability after oral administration. border-bottom: 1px solid #d2d2d2; ; Iborra-Clar, M.I. /* homepage lead banner adjustments */ The solubility of codeine is 9000 mg/L at 20 C. The evaluation was based upon activity coefficients, capacity, and selectivity values. margin: 0; ; Hashim, M.A. Since there is no research on IL-based ELM applications for Ibf extraction, the identified IL was used in this work to develop an ionic liquid-based green emulsion liquid membrane (ILGELM) for Ibf extraction. government site. A 10% concentration of drug maximizes the bulk and porosity of the product. } The thermodynamic parameters for the solubilization process are presented. In an acylation reaction, an acyl group (RCO-) is attached to the benzene ring producing a ketone. All other materials used were of analytical grade. A carriersolvent ratio of 1:2 offers the greatest increase in bulk and porosity. In the UK, the cheapest and most available preparation is the generic pack consisting of 32 tablets, each containing 8mg codeine phosphate and 500mg paracetamol, usually available from neighborhood pharmacies. Hydrogen gas is used to reduce the ketone to an alcohol in the presence of a catalyst (Raney nickel): Addition of CO to the alcohol to form the carboxylic acid using carbon monoxide and a catalyst (palladium): Ibuprofen is a carboxylic acid, it will react with hydrogencarbonate solutions to produce a salt, water and carbon dioxide gas. Paracetamol has a solubility of 14,000 mg/L at 25 C[2]. Most drugs are administered in a solid form, and low aqueous solubility can either delay or limit drug absorption. A selected IL was used to develop an ILGELM. and M.G. } Khan, A.; Shams, D.F. The change in the slope of H versus Ghm curves for aqueous systems indicated that two different mechanisms contribute to the solubility of ibuprofen depending on the nature of the solvent system. The maximum increase in bulk and porosity occurs at the boiling point of the solvent. Rezaei Motlagh, S.; Harun, R.; Awang Biak, D.R. Due to its adverse effects upon aquatic organisms and humans, the removal and recovery of Ibf are essential. Figure 5 shows the decrease of drug crystallinity in the solid dispersion. Fernandes AR, Ferreira NR, Fangueiro JF, Santos AC, Veiga FJ, Cabral C, Silva AM, Souto EB. /* view for ispeak top filter */ The stability of ILGELM can be determined by calculating the breakage of ELM. Zaulkiflee, N.D.; Ahmad, A.L. ; Fadhilah, A.; Rosyadi, R.; Yahya, W.Z. } About | The flask was heated, and then the boiling concentrated polymer solution was subjected to sudden vacuum at 760 mmHg to yield a porous mass. Ibuprofen (Ibf) is a biologically active drug (BADs) and an emerging contaminant of concern (CECs) in aqueous streams. The ibuprofen salt solubility in deionised water and two buffer solutions at pH 5.4 and 7.4 were established and compared with the parent acid solubility. padding: 1rem; Department of Chemical Engineering, Universiti Teknologi PETRONAS, Seri Iskandar 32610, Malaysia, International Institute for Halal Research and Training (INHART), International Islamic University Malaysia, Kuala Lampur 53100, Malaysia, Center of Research in Ionic Liquids, Universiti Teknologi PETRONAS, Seri Iskandar 32610, Malaysia, Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744, Moto-oka, Fukuoka 819-0395, Japan. Smith, K.B. color: #fff; Unauthorized use of these marks is strictly prohibited. div.js-form-item.form-item.js-form-type-select.form-item-year.js-form-item-year { A list of the chemicals used and their properties is present in, The calculations were performed using COSMOtherm (18.0.2 version, ImbacherWeg, Leverkusen, Germany) software. .tabs.tabs-strip .tabs-title a[aria-selected='true'] { /* fix file attachment spacing */ ; Kibria, M.G. Once the tablets have absorbed the water, they will swell up and can now be easily mixed with a fork. Goyal, R.K.; Jayakumar, N.S. Please enable it to take advantage of the complete set of features! Once the solution has passed through the filter the precipitate should be washed with a small amount of cold water to dissolve and harvest any, If one wants to consume the entire solution immediately after extraction, one will just drink the. this article in other publications, without requesting further permission from the RSC, WebMolecular-Level Understanding of the Encapsulation and Dissolution of Poorly Water-Soluble Ibuprofen by Functionalized Organic Nanotubes Using Solid-State NMR Spectroscopy. ; Shu, L.Y. .homepage-feature-banners .field-items .field-item:nth-child(2) .field-name-field-banner-heading, Notice that the only functional group is the benzene ring. #webform-submission-headshot-update-request-add-form table th { Ibuprofen is practically insoluble in water at room temperature, which allows for a very simple extraction process. It is possible to buy the lysine salt of ibuprofen, ibuprofen lysine. /* New ui component for Video Slider */ Othman, N.; Noah, N.F. West Pomeranian University of Technology, Szczecin, Faculty of Chemical Technology and Engineering, Department of Chemical Organic Technology and Polymeric Materials, Piastw Ave. 42, 71-065 Szczecin, Poland Additional porous solid dispersions were prepared by increasing the concentration of drug (i.e., 5%, 7.5%, 10%, 12.5% of the total weight of polymer). The structural formula is represented below: ; Johl, S.K. The amount of drug was measured form the absorbance of UV spectrophotometer at 214nm. 2021 Sep 13;13(9):1457. doi: 10.3390/pharmaceutics13091457. Aqueous solubility is an important parameter for the development of liquid formulations and in the determination of bioavailability of oral dosage forms. Ibuprofen (IB), a nonsteroidal anti-inflammatory drug, is a chiral molecule and is currently used clinically as a racemate (racIB).

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