For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult a healthcare professional. b Swelling grade 3: >100mm/>10cm; grade 4: necrosis/exfoliative dermatitis. We explain the risks of, How the ongoing stigma surrounding the LGBTQ community connects to the HIV/AIDS crisis, how monkeypox is disproportionately affecting the Queer. COVID arm should also not stop you from getting your second shot. (2021). Its also important to talk with your doctor to learn more about the COVID-19 vaccine. a Fever Grade 3: 39.0 40.0C or 102.1 104.0F; Grade 4: >40.0C or >104.0F Injection site redness and swelling following either dose was reported slightly less frequently and was more common after dose 2 than dose 1. In the meantime, you can get relief with warm compresses and over-the-counter pain medications. Materials in this section are updated as new information and vaccines become available. Even though its not serious, COVID arm can be uncomfortable. A detailed discussion of strategies to reduce procedural pain can be found here. Axillary swelling or tenderness was the second most frequently reported local reaction. Some of the evidence-based strategies for reducing procedural pain in children can also be used to help prevent distress and alleviate fear in adults. No grade 4 local reactions were reported. It will join the Pfizer-BioNTech and Moderna COVID-. Serious adverse events were defined as any untoward medical occurrence that resulted in death, was life-threatening, required inpatient hospitalization or prolongation of existing hospitalization, or resulted in persistent disability or incapacity. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. The AstraZeneca vaccine Vaxzevria is a vaccine against COVID-19. The majority of systemic reactions were mild or moderate in severity, after both doses. In the older age group, the most common serious adverse event occurring at higher rates in the vaccine group than the placebo group was pneumonias (2 cases in vaccine group vs. 0 cases in placebo group). Headache and fatigue were the most common reactions. Any severe skin reaction after the vaccine is also very rare. . Enlarged lymph nodes are common after the Covid-19 vaccine and are your body's normal reaction to the vaccine. National Library of Medicine While there is limited data on giving COVID-19 vaccines with other vaccines, including flu vaccines, experience with giving other vaccines together has shown the way our bodies develop protection and possible side effects are generally similar when vaccines are given alone or with other vaccines. Vaccine availability is subject to . See this image and copyright information in PMC. There were no grade 4 local reactions reported. if( 'moc.enilnoefiltseb' !== location.hostname.split('').reverse().join('') ) { aGrade for fever: Any 38.0C; grade 3=39.6-40.0C; grade 4=> 40.0C. The COVID-19 vaccine has shown to have high efficacy if given correctly intramuscularly. J Dermatol. sound information and advice to make the smartest, healthiest choices. "Reports of lymphadenopathy were imbalanced with 1.1 percent of persons in the vaccine group and 0.6 percent in the placebo group reporting such events," the CDC notes. See chart below to identify the route for each injectable vaccine. Multiple studies have found that COVID-19 vaccines, including boosters, are safe, and that adverse reactions are rare. a Fever Grade 3: 39.0 40.0C or 102.1 104.0F; Grade 4: >40.0C or >104.0F This happens with many of the common vaccines that infants receive, such as DTaP, polio, PCV, hepatitis A and B, chickenpox, MCV, and influenza. Fever was more common after the second dose (23.9%) compared to the first dose (3.3%). If multiple vaccines are administered at a single visit, administer each injection in a different injection site. Drago F, Ciccarese G, Guadagno A, Parodi A. J Eur Acad Dermatol Venereol. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. bGrade 3: prevents daily activity; Grade 4: emergency room visit or hospitalization for severe pain at the injection site. Any AEFI should be reported to the vaccine safety service in your state. Wei N, et al. Severe, life-threatening reactions following vaccinations are rare. Gum disease. The majority of systemic events were mild or moderate in severity, but there was a higher occurrence of grade 3 or higher reactions in the vaccine group. Treating COVID arm will not reduce your immune systems response to the vaccine. During the study period, there were 322 patients referred for post-COVID-19 vaccine cutaneous reactions. The lymphatic system is home to your immune system; so when you get checked out for a cold or strep throat or flu, your doctor will feel your neck area. ACS Central Sci 2021; 7: 512533. Adverse events in the vaccine group were similar in nature and incidence to those in the placebo group, with the exception of higher incidence of injection site erythema in the vaccine group compared to the placebo group (1.3% vs 0.2%) and COVID-19 in the placebo group compared to the vaccine group (5.5% vs 3.1%). Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Vaccine recipients reported higher rates of local reactions after dose 2 than dose 1. if( navigator.sendBeacon ) { COVID arm: Very delayed large injection site reactions to mRNA COVID vaccines. While this might seem strange or alarming, doctors want to assure patients that it's actually totally normal, even though it's on the rare side as far as side effects go. You can review and change the way we collect information below. Millions of people worldwide are getting vaccinated, so even small occurrences of vaccine reactions and side effects are getting lots of attention. sharing sensitive information, make sure youre on a federal Procedural Pain Management e Chills Grade 3: prevented daily activity and required medical intervention; Grade 4: required emergency room visit or hospitalization. Thank you for taking the time to confirm your preferences. They may also affect other parts of the body. It's not yet approved for use in the United States. We pay our respects to their Elders, past, present and emerging. The main imbalances between the vaccine and placebo groups were general disorders and administration site conditions, consistent with the known reactogenicity profile of the vaccine. Last medically reviewed on November 27, 2022. Fever, headache, abdominal pain, diarrhea, nausea, and vomiting can happen after live typhoid vaccine. Women who got . It. Other common infections can also cause swollen lymph nodes, such as: Abscessed or impacted teeth. Redness and swelling were more common after dose 2. Coronavirus (COVID-19) Update: FDA authorizes emergency use of Novavax COVID-19 vaccine, adjuvanted. Typically, an injection-site reaction is considered to be any pain, swelling, rash, bleeding, or redness that occurs at the site of an injection, although, serious reactions can occur (see sidebar 1 ). Use combination vaccines (e.g., DTaP-IPV-HepB or DTaP-IPV/Hib) to reduce the number of injections, when appropriate. After dose 1, the younger age group reported pain more frequently than the older age group (86.9% vs 74.0%); a similar pattern was observed after dose 2 (90.1% vs 83.4%). There was one report of grade 4 fatigue and one report of grade 4 arthralgia, both in the younger age group after dose 1. Bojan Story/Getty Images. If you get a COVID-19 vaccine and you think you might be having a severe allergic reaction after leaving the vaccination provider site, seek immediate medical care by calling 911. Before 3. doi: 10.1111/jdv.18418. 2022 Melbourne Vaccine Education Centre. It wont escalate to a life threatening condition or serious allergic reaction and is not associated with anaphylaxis. Abstracts of Presentations at the Association of Clinical Scientists 143. Evidence-based strategies to reduce procedural pain include: Fear of injections is often a reason why adults, including health care personnel, decline vaccines. The possibility that the vaccine contributed to the serious adverse event reports of rheumatoid arthritis (n=1), peripheral edema/dyspnea with exertion (n=1), and autonomic dysfunction (n=1) cannot be excluded. A 2021 case report showed that the Pfizer-BioNTech vaccine might also cause COVID arm but appears less likely to do so. It is recommended that future vaccines continue to be given according to the immunisation schedule. Disclaimer. An imbalance of unsolicited adverse events in the skin and subcutaneous tissue disorders was also observed between the vaccine group (2.4%) and placebo group (1.0%). Delayed localized hypersensitivity reactions to the Moderna COVID-19 vaccine a case series. For this reason, everyone who receives a COVID-19 vaccine is monitored by their vaccination provider for at least 15 minutes. The proportions of participants who reported at least one serious adverse event were 0.2% in the vaccine group and 0.2% in the placebo group. The vaccines often cause swelling in the armpit or underarm that can mimic the lumps associated with breast cancer, causing some women undue concern. Injection site nodules The development of a nodule at the injection site is a known but rare adverse event following immunisation (AEFI). The most common manifestations of localized injection-site reactions were swelling (44% after the first dose, 68% after the second), erythema (49% and 67%), and pain (35% and 59%). 2023 Feb;158:114208. doi: 10.1016/j.biopha.2022.114208. (2022). Elyoussfi DS, et al. The median duration of lymphadenopathy was 1 to 2 days. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Saving Lives, Protecting People. Pain at the injection site was reported more frequently after dose 1 (93.1%) than after dose 2 (92.4%). However, if you feel a lump in your armpit that lasts for more than six weeks. c Axillary swelling or tenderness was collected as a solicited local adverse reaction (i.e., lymphadenopathy: localized axillary swelling or tenderness ipsilateral to the vaccination arm); grade 3: any use of prescription pain reliever or prevented daily activity; grade 4: required emergency room visit or hospitalization. Injection site reactions will go away on their own. COVID arm is a rare reaction. Some nodules can become symptomatic and last for months or even years and are referred to as persisting subcutaneous nodules. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Detailed discussion can be found here: Multiple Injections/Coadministration of Vaccines, COVID-19 vaccine and coadministration with other vaccines, Routine and Influenza Immunization Services During the COVID-19 Pandemic: Interim Guidance | CDC, Vaccine Administration: Intramuscular (IM) Injection Children 7 through 18 years of age, Vaccine Administration: Intramuscular (IM) Injection Adults 19 years of age and older], Vaccine Administration: Needle Gauge and Length, Giving all the Doses Under 12 Months of Age, COVID-19 vaccines can be given during the same visit, How to Hold Your Child During Vaccinations, General Best Practice Guidelines for Immunization: Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP), Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline, Subcutaneous (SC or Subcut) Injection: Sites [3:26 minutes], Subcutaneous (SC or Subcut) Injection: Administration [6:27 minutes], Intramuscular Injection: Sites [5:07 minutes], Live, Attenuated Influenza Vaccine (LAIV) [4:09 minutes], Comfort and Restraint Techniques for Children [4:46 minutes], You Call the Shots: Vaccine administration training for healthcare professionals, National Center for Immunization and Respiratory Diseases, Healthcare Professionals / Providers Home, Vaccine Adverse Event Reporting System (VAERS), Pediatric Vaccination Practices During COVID-19, Childhood Vaccination Toolkit for Clinicians, You Call The Shots: Vaccine Storage and Handling, Screen for Contraindications and Precautions, Temporary, Satellite, or Off-Site Vaccination Clinics, Easy-to-Read Recommended Immunization Schedules, Resources for Parents of Infants and Toddlers, Resources for Parents of Preteens and Teens, Resources for College Students, Young Adults, and Adults, Understanding Risks & Responsibilities, If You Choose Not to Vaccinate, Talking with Parents about Vaccines for Infants, Understanding Vaccines and Vaccine Safety, U.S. Department of Health & Human Services, DTaP, DT, HepA, HepB, Hib, HPV, , IIV4, RIV4, ccIIV4, IPV*, MenACWY, MenB, PCV13, PPSV23*, RZV, Td, Tdap, TT, Fatty tissue of thigh for infants younger or upper outer triceps area, DTaP-IPV, DTaP-IPV-HepB, DTaP-IPV/Hib, DTaP-IPV-HepB/Hib, HepA-HepB. Authorities at the FDA are likely to authorize the use of Johnson & Johnson's new COVID-19 vaccine. There were 13 fever events >40C reported: 11 (0.4%) participants in the vaccine group and 2 (0.2%) in the placebo group among the 2 to 5-year-old-age group. Please refer back to the website to ensure all reference information is current and up-to-date. Virus Res 2021; 17: 198454. Intensified itching and a change in size of the nodule has been reported when a child is unwell with a viral infection or even following subsequent vaccinations given at a different anatomical site. A higher frequency of unsolicited adverse events was reported in the vaccine group compared to the placebo group (29.6% vs 25.1%). Would you like email updates of new search results? Notably, about 2weeks before the manifestation of purpuric skin lesions she had her first. Detailed discussion can be found here: Pinkbook: Vaccine Administration | CDC 2023 Feb 9;11(2):397. doi: 10.3390/vaccines11020397. asevere: >10 cm; Grade 4: necrosis (redness and swelling categories) or exfoliative dermatitis (redness category only). Clipboard, Search History, and several other advanced features are temporarily unavailable. Centers for Disease Control and Prevention. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Local reactions were reported by the majority of vaccine recipients and at higher rates than placebo recipients. CDC twenty four seven. Pain at the injection site was the most frequent and severe reported solicited local reaction among vaccine recipients. Fever was more common after the second dose (12.1%) compared to the first dose (2.5%). If you have questions about receiving a COVID-19 vaccination at a specific location, please contact that location. For both age groups, fatigue, headache and myalgia were the most common. Additional information on providing immunization services during a pandemic is available here: Routine and Influenza Immunization Services During the COVID-19 Pandemic: Interim Guidance | CDC. As more and more people get their shots, they're noticing a lump in the armpit of the arm where they got vaccinated. COVID-19 vaccination significantly lowers your risk of severe illness, hospitalization, and death if you get infected. Nodules are defined as the presence of a palpable, firm, discrete or well-demarcated soft tissue lump at the site of immunisation in the absence of heat, erythema (redness) or signs of abscess. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Nodules are defined as the presence of a palpable, firm, discrete or well-demarcated soft tissue lump at the site of immunisation in the absence of heat, erythema (redness) or signs of abscess. Saving Lives, Protecting People, National Center for Immunization and Respiratory Diseases, Use of COVID-19 Vaccines in the U.S.: Appendices, FAQs for the Interim Clinical Considerations, Myocarditis and Pericarditis Considerations, Jurisdictions: Vaccinating Older Adults and People with Disabilities, Vaccination Sites: Vaccinating Older Adults and People with Disabilities, Vaccinating Patients upon Discharge from Hospitals, Emergency Departments & Urgent Care Facilities, Vaccines for Children Program vs. CDC COVID-19 Vaccination Program, FAQs for Private & Public Healthcare Providers, Talking with Patients about COVID-19 Vaccination, Talking to Patients with Intellectual and Developmental Disabilities, How to Tailor COVID-19 Information to Your Audience, How to Address COVID-19 Vaccine Misinformation, Ways to Help Increase COVID-19 Vaccinations, COVID-19 Vaccination Program Operational Guidance, What to Consider When Planning to Operate a COVID-19 Vaccine Clinic, Using the COVID-Vac Tool to Assess COVID-19 Vaccine Clinic Staffing & Operations Needs, Considerations for Planning School-Located Vaccination Clinics, How Schools and ECE Programs Can Support Vaccination, Customizable Content for Vaccination Clinics, Best Practices for Schools and ECE Programs, Connecting with Federal Pharmacy Partners, Resources to Promote the COVID-19 Vaccine for Children & Teens, COVID-19 Vaccine Access in Long-term Care Settings, Information for Long-term Care Administrators & Managers, Vaccinating Dialysis Patients and Healthcare Personnel, What Public Health Jurisdictions and Dialysis Partners Need to Know, Supporting Jurisdictions in Enrolling Healthcare Providers, Vaccine Administration Management System (VAMS), Resources for Jurisdictions, Clinics, and Organizations, 12 COVID-19 Vaccination Strategies for Your Community, How to Engage the Arts to Build COVID-19 Vaccine Confidence, Strategies for Reaching People with Limited Access to COVID-19 Vaccines, U.S. Department of Health & Human Services, Use of antipyretic or pain medication, n (%). 2022 Dec;36(12):e979-e981. A nodule can persist for weeks and sometimes months. What We Know About the Side Effects of Pfizers COVID-19 Vaccine, What You Should Know About the AstraZeneca COVID-19 Vaccine, COVID-19 Vaccine Side Effects: What to Know Now, Monkeypox and the Smallpox Vaccine: Your Questions Answered. a Pain grade 3: any use of prescription pain reliever or prevented daily activity; grade 4: required emergency room visit or hospitalization. The proportions of participants who reported at least one serious adverse event were 0.5% in the vaccine group and 0.2% in the placebo group. Since the COVID-19 vaccines are new, we dont know definitively what exact mechanism triggers COVID arm symptoms. 2005-2023 Healthline Media a Red Ventures Company. The development of a nodule at the injection site is a known but rare adverse event following immunisation (AEFI). These cookies may also be used for advertising purposes by these third parties. The rabies vaccine can save your life after a bite or scratch from an unvaccinated animal. Therapists say it can damage your connection. Pain at the injection site was the most frequent and severe reported solicited local reaction among vaccine recipients. Careers. The symptoms of COVID arm typically last about 5 days but may last as long as 21 days. 2022 Sep;21(9):3692-3703. doi: 10.1111/jocd.15209. Injecting the most painful vaccine last when multiple injections are needed can decrease the pain associated with the injections. Learn whether a previous smallpox vaccine can protect you against the current monkeypox outbreak. They may happen right after, within a day, or within 2-3 days. Thank you for taking the time to confirm your preferences. In the placebo group serious adverse events, 1 participant experienced an abdominal wall abscess and 1 participant with rhinovirus infection and asthma. (d) Generation of autoreactive lymphocytes and crossreactive antibodies due to molecular mimicry leading to autoimmune reactions, such as vaccineinduced immune thrombocytopenia (VIIT) lupus erythematosus, vasculitis and bullous pemphigoid. Observe recipients after vaccination to decrease the risk for injury should they faint. 8600 Rockville Pike Some persons should be observed longer30 minutesafter receiving COVID-19 vaccine. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Grade 4 fever (>40.0C) was reported by one vaccine recipient after dose 2 and one placebo recipient after dose 2. It resolves on its own within a few days. There were 7 SAEs among 6 participants in the vaccine group (appendicitis, cellulitis, cellulitis orbital, type 1 diabetes mellitus, appendicitis, pyelonephritis and urosepsis). COVID arm may feel mildly uncomfortable, but the reaction is not dangerous and will clear on its own. (2021). Serious adverse events were defined as any untoward medical occurrence that resulted in death, was life-threatening, required inpatient hospitalization or prolongation of existing hospitalization, or resulted in persistent disability or incapacity. Typical side effects for all COVID-19 vaccines are mild and require little more than rest. Local reactions in both groups were mostly grade mild or moderate; however, severe reactions were more frequent in the vaccine group than in the placebo group. E, et al Nodule at injection site as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation, Vaccine 2004 (22): 575-585, Silcock, R. et al Subcutaneous nodules following immunization in children; in Victoria, Australia from 2007 to 2016, Vaccine 2020 (38): 3169-3177, Silcock, R. et al Subcutaneous nodules: an important adverse event following immunization, Expert Review of Vaccines 2019 (18): 405-410, Bergfors, E. Lundmark, K. Kronander, U. FOIA Nodules can occur following any vaccine. b mild: no interference with activity; moderate: some interference with activity; severe: prevents daily activity; Grade 4: emergency room visit or hospitalization, Systemic reactions were reported by the majority of vaccine recipients and at higher rates than placebo recipients. Effect of COVID-19 (SARS-CoV-2) Vaccination on Patients with Atopic Dermatitis Treated with Dupilumab: A Multicenter, Observational Study. Referral to a Specialist Immunisation Clinic should be considered for specialist consultation. Ensure correct vaccine administration for both intramuscular and subcutaneous vaccines. If you get the Moderna COVID-19 vaccine, there is a small chance that you could develop a skin reaction. A severe allergic reaction can cause: difficulty breathing or wheezing, a drop in blood pressure, swelling of the tongue or throat, or Lindgren AL, et al. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Provide supportive care and take appropriate measures to prevent injuries if such symptoms occur. The CDC recommends an mRNA vaccine over the J&J vaccine. Injection site redness and swelling following either dose were reported less frequently. The majority of solicited local reactions occurred within the first 2 days after any dose, persisting for a median of 3.0 days. According to the CDC, the only instances in which you may need to contact your doctor or healthcare provider is if the redness or tenderness where you got the shot increases after 24 hours or "ifyour side effects are worrying you or do not seem to be going away after a few days." COVID arm is a harmless immune system reaction that some people have after getting the Moderna vaccine. Online ahead of print. COVID arm is thought to be an immune system reaction. Read on to find out more about this reaction and for another heads-up about vaccinations, know that This COVID Vaccine Side Effect Could Show Up a Week After Your Shot. Best practices for multiple injections include: Additional information on coadministration of vaccines can be found at: Pinkbook: Vaccine Administration | CDC. One case of Bells palsy in the vaccine group was considered a serious adverse event. ae0fcc31ae342fd3a1346ebb1f342fcb. Adults and children may have some side effects from a COVID-19 vaccine, including pain, redness or swelling at the injection site, tiredness, headache, muscle pain, chills, fever, and nausea. Axillary (or groin) swelling or tenderness was reported slightly more frequently in the younger age group than the older age group (9.3% vs 9.1% after dose 2). After dose 1, the older age group reported pain more frequently than the younger age group (61.4% vs 37.4%); a similar pattern was observed after dose 2 (71.4% vs 46.2%). You might notice a lump behind your ear when you get sick. We avoid using tertiary references. If you have any concerns about the accuracy of our content, please reach out to our editors by e-mailing In the placebo group there was 1 participant with bronchiolitis, rhinovirus and acute respiratory failure. Unspecific injection-site reactions very early occurring after the vaccination are most frequent. (2022). No other systemic grade 4 reactions were reported. * Grade 4 event reported due to error in eDiary data entry, event was actually grade 0 (100.0F). COVID arm that appeared in the contralateral upper extremity after mRNA-1273 booster inoculation. Deviation from the recommended route may reduce vaccine efficacy or increase local adverse reactions. A child with a long-standing, intensely itching subcutaneous nodule on a thigh: an uncommon (?) We adhere to structured guidelines for sourcing information and linking to other resources, including We explain how it works and more. The frequency of systemic reactions was higher in the younger age group than the older age group (81.9% vs 71.9% after dose 2). Reports of lymphadenopathy were imbalanced with 1.1 % of persons in the vaccine group and 0.6% in the placebo group reporting such events; lymphadenopathy is plausibly related to the vaccine. Some patients are reporting a lump in their armpit after getting the COVID vaccine. But even before the vaccines were being administered in the States, medical experts were warning Americans to prepare for some noticeable side effects post-shot. -. (2021). 2023 Feb 6:S0365-0596(23)00008-9. doi: 10.1016/j.abd.2022.04.010. Federal government websites often end in .gov or .mil. Recently, people who have been vaccinated are sharing stories online about feeling lumps in their armpits, which might seem like cause for concern, but is in fact, to be expected. A safety recall issued by the manufacturer affects 460,769 cars around the world. (2022). Pain at the injection site was more common post Dose 2 (94.8%) than Dose 1 (93.1%). Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. There is growing evidence that not only the novel coronavirus disease (COVID-19) but also the COVID-19 vaccines can cause a variety of skin reactions. If gloves are worn, they should be changed, and hand hygiene should be performed between patients. No specific safety concerns were identified among vaccine recipients aged 6 months5 years. Headache and fatigue were the most common systemic reactions. Lump at the injection site Why it happens Duration Treatment Contacting a doctor Summary Most people experience minor side effects following COVID-19 vaccination. An increase in the incidence of injection site conditions were seen in the vaccine group (9.8%) compared to the placebo group (4.1%). Pityriasis rosea-like rashes and reactivation of herpes zoster have also been reported after COVID-19 vaccination. Bestlifeonline.com is part of the Meredith Health Group. The history of, or presence of, a nodule is not a contraindication to future vaccines. We take your privacy seriously. 2021 The Authors. Three serious adverse events were considered by the U.S. Food and Drug Administration (FDA) as possibly related to vaccine: the one report of intractable nausea/vomiting and two reports of facial swelling in persons who had a previous history of cosmetic filler injections. The COVID-19 vaccine can cause some commonly known side effects. Another complication of the mRNA vaccine can be myocarditis. PMC They help us to know which pages are the most and least popular and see how visitors move around the site. Allergic reactions after COVID-19 vaccination. If you are currently eligible to get vaccinated, click the Find COVID-19 Vaccines button to find a vaccination location and schedule an appointment with the specific vaccine provider or pharmacy. asevere: > 50 mm; Grade 4: necrosis or exfoliative dermatitis, bsevere: prevents daily activity; Grade 4: emergency room visit or hospitalization, a Grade 3: > 100 mm; Grade 4: necrosis or exfoliative dermatitis. bsevere: any use of prescription pain reliever/prevents daily activity; Grade 4: emergency room visit or hospitalization for severe pain at the injection site. Solicited systemic adverse reactions were most common in the vaccine group than the placebo group and after dose 2 compared to dose 1. Eleven (52%) had received the Moderna mRNA vaccine while the remaining 10 (48%) received the Pfizer-BioNTech mRNA vaccine. Incidence of lymphadenopathy was higher in the vaccine group (0.7%) than the placebo group (<0.1%). Pain at the injection site was the most frequent and severe reported solicited local reaction among vaccine recipients. The Johnson & Johnson vaccine or the recently approved Novavax have not been associated with this side effect. What Are the Side Effects of the COVID-19 Vaccine? b Headache Grade 3: significant; any use of prescription pain reliever or prevented daily activity; Grade 4: required emergency room visit or hospitalization. There were 2 SAEs among 2 recipients (obstructive nephropathy and suicide attempt). Usually, this lump or swelling will appear within 24 hours of the vaccination and lasts for anywhere from three to seven days afterward.

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